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Analysis of renal expression of LRG-1 (leucine-rich alpha-2-glycoprotein 1) in pathophysiology of kidney disease

Analysis of renal expression of LRG-1 (leucine-rich alpha-2-glycoprotein 1) in pathophysiology of kidney disease - Analysis of LRG1 expression in kidney disease

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000021770
Enrollment
120
Registered
2016-04-05
Start date
2016-07-13
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney disease, hypertension, cardiovascular disease

Interventions

None listed

Sponsors

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients who are going to undergo renal biopsy for the scrutiny of kidney disease, and those who already underwent renal biopsy for the same purpose. 2. Patients who already underwent nephrectomy and whose resected renal tissues are preserved in the tissue repository.

Exclusion criteria

Exclusion criteria: Patients who are considered inappropriate for inclusion in the study.

Design outcomes

Primary

MeasureTime frame
The distribution of LRG1 in the normal kidney tissues of dissected kidney by nephrectomy and in the renal biopsy specimens derived from diseased kidney, and its relationship with parameters of renal function, CKD CGA classification, diabetic nephropathy classification, and renal events (serum creatinine doubling, dialysis induction and total mortality.

Secondary

MeasureTime frame
Parameters of renal and cardiovascular function, glucose, lipid and electrolyte metabolism, renin-angiotensin system, urinary fibrotic and inflammatory factors, and ambulatory blood pressure monitoring.

Countries

Japan

Contacts

Public ContactDr. Sona Haku

Yokohama City University Graduate School of Medicine Department of Medical Science and Cardiorenal Medicine

t106048f@yokohama-cu.ac.jp045-787-2635

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026