The effect of probiotics and resistance exercise on cognitive function, physical performance, and intestinal flora in the elderly: a randomized, double-blind, placebo-controlled trial

The effect of probiotics and resistance exercise on cognitive function, physical performance, and intestinal flora in the elderly: a randomized, double-blind, placebo-controlled trial - The effect of probiotics and resistance exercise on cognitive function, physical performance, and intestinal flora in the elderly

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021749

Enrollment

Registered

2016-04-14

Start date

2016-04-14

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly adults

Interventions

Probiotic supplementation and resistance exercise for 12 weeks. - Supplementation: 2 gram-powder per day - Exercise: participation of 90 min-exercise class and additional exercise at home Placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Japanese 2) Age >=60 years 3) Not receiving care authorization in the Long-Term Care Insurance Law 4) Stretching and exercise over 1 year 5) Informed consent provided 6)Able to receive and take experimental supplements 7) Able to follow the instructions of the study team

Exclusion criteria

Exclusion criteria: 1) Disease that exercise is prohibited from doctor (cardiovascular disease or other) 2) The diagnosis of dementia by a physician/taking medicine for dementia 3) Food allergy against materials in experimental supplements 4) Subjects judged by the investigator/project leader to be ineligible for other reasons

Design outcomes

Primary

Measure	Time frame
Cognitive function - pre and post 12 week-intervention - single measurement, respectively	—

Secondary

Measure	Time frame
Physical performance, Frailty scale, Intestinal flora, Bowel movements, Psychological parameters, Blood examination, Inflammatory markers, Body composition measured electrical impedance equipment - pre and post 12 week-intervention - single measurement, respectively	—

Countries

Japan

Contacts

Public ContactNarumi Nagai

University of Hyogo School of Human Science and Environment

nagai@shse.u-hyogo.ac.jp+81-79-292-1515

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026