Anti-VEGF and steroid combination therapy for diabetic macular edema

Anti-VEGF and steroid combination therapy for diabetic macular edema - Combination therapy for DME

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021630

Enrollment

Registered

2016-03-27

Start date

2015-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetic macular edema

Interventions

Two months after loading phase treatment of intravitreal ranibizumab injection(IVR), we perform extra injection of IVR. Two months after loading phase treatment of intravitreal ranibizumab injection(

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Type I,II diabetes patients over 20 yrs old with IC. 2)Patient with Clinically Significant Macular Edema(CSME)and diffuse macular edema difficult to treat only with laser phitocoagulation(PC). 3)VA disturbances due to DME,not due to diabetic retinopathy. 4)LogMAR BCVA 1.52-1.22 5)Central retinal thickness(by 1 mm of OCT retinal map)over 300 microm.

Exclusion criteria

Exclusion criteria: 1)Patients treated PC within 3 months before treatment. 2)Ischemic maculopathy with FA. 3)Vitreal macular traction 4)Proliferative diabetic retinopathy 5)Glaucoma 6)Optic neuropathy 7)Past history of vitreous surgery 8)Phakic eyes 9)Any history of intravitreal injection or subtenon injection. 10)Past history of cataract surgery. 11)Steroid respondar 12)Heart failure, cerebral vascular disease,hematological dissease, tumor. 13)Patients receive general steroid treatment. 14)Hheavy renal failure over stageIII. 15)GradeIII HT 16)HbA1c NGSP over 10%

Design outcomes

Primary

Measure	Time frame
The number of anti-VEGF injection.	—

Countries

Japan

Contacts

Public ContactMasahiko Sugimoto

Mie Universivt, School of Medicine Ophthalmology

sugmochi@clin.medic.mie-u.ac.jp0592315027

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026