chronic pain
Conditions
Interventions
Cerebral blood flow will be investigated by the resting-state fMRI, brain metabolites by MR-spectroscopy, brain gray matter volume by Voxel-based Morphometry, comparing the subjects with chronic low b
Sponsors
Fukushima Medical University Department of Orthopaedic Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Continuous pain of more than 3 month (12 weeks). 2. Pain with more than a 3 NRS (Numeric Rating Scale) point maximum in one day.
Exclusion criteria
Exclusion criteria: 1. History of spine surgery. 2. Evidence of vertebral fracture, tumor (original or metastasizing), inflammatory disease (pyogenic spondylitis, etc.). 3. Pain caused by traffic accident or trauma. 4. With dementia. 5. Severe or unstable neuropsychiatric disease. 6. Brain disease (infarction or encephalorrhagia, etc.) or spinal cord disease. 7. Inability to keep rest position due to pain. 8. Contraindication for MRI. (that is patient with implanted cardiac pacemakers, aneurysm clip, metal implant, pregnancy or claustrophobia.) 9. No consent for present trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantity of brain metabolite obtained by magnetic resonance spectroscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain volume changes obtained by voxel based morphometry, brain activity analysis using functional MRI | — |
Countries
Japan
Contacts
Public ContactTakuya Kameda
Fukushima Medical University Orthopaedic Surgery
Outcome results
None listed