non-erosive gastroesophageal reflux disease (NERD) resistant to proton-pump-inhibitors (PPIs)
Conditions
Interventions
None listed
Sponsors
Depertment of 2nd. internal medicine, Osaka Medical Collage
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (i) Principal complaint: dysphagia. (ii) Organic disease ruled out by upper gastrointestinal endoscopy. (iii) Experienced no alleviation of symptoms despite use of the standard PPI dose for at least 8 weeks.
Exclusion criteria
Exclusion criteria: (i) Drug administration and/or endoscope insertion made difficult by constriction or deformation of the upper gastrointestinal tract. (ii) Suffering from active malignant tumors, or other serious, systemic complications. (iii) Suffering from active ulcers. (iv) Suffering from serious complications, such as heart, kidney, liver, or respiratory failure. (v) A history of treatment of the upper abdomen with radiotherapy. (vi) A history of surgical treatment of the gastrointestinal tract.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study was carried with patients who had been diagnosed as having PPI-resistant NERD, showed no erosive esophageal mucosal damage, and showed no alleviation of dysphagia symptoms after administration of standard doses of PPIs for at least 8 weeks. After enrolment, the presence or absence of esophageal motility disorder was evaluated on the basis of the Chicago classification, using HRM. | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy of the PPI for NERD | — |
Countries
Japan
Contacts
Public ContactToshihisa Takeuchi
Osaka Medical Collage Depertment of 2nd. internal medicine
Outcome results
None listed