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A randomized, double-blind, parallel-group study to evaluate the effect of alkalized lidocaine on hemodynamic changes during tracheal intubation.

A randomized, double-blind, parallel-group study to evaluate the effect of alkalized lidocaine on hemodynamic changes during tracheal intubation. - A randomized, double-blind, parallel-group study to evaluate the effect of alkalized lidocaine on hemodynamic changes during tracheal intubation.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000021563
Enrollment
60
Registered
2016-03-25
Start date
2016-03-25
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who undergo surgeries under general anesthesia.

Interventions

Laryngotrachal application of lidocaine before tracheal intubation. Laryngotrachal application of alkalized lidocaine before tracheal intubation. Laryngotrachal application of saline before tracheal

Sponsors

Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adult patients (ASA physical status I or II) who required a tracheal intubation during general anesthesia.

Exclusion criteria

Exclusion criteria: Patients with anticipated difficult airway, patients who scheduled for surgery with nasotracheal intubation, patients who were pretreated with beta-blockers, patients who scheduled for surgery with epidural anesthesia, spinal anesthesia or nerve block in addition to general anesthesia, pregnant or lactating women, and paients who are allergic to local anesthetics.

Design outcomes

Primary

MeasureTime frame
Changes in blood pressure and heart rate during tracheal intubation.

Secondary

MeasureTime frame
The degree of sore throat assessed by using a visual analogue scale (VAS, 0-100 mm) and hoarseness, dysphonea, nausea and vomitting are systematically evaluated as present or absent just after and at 15 minutes and 24 hours after extubation.

Countries

Japan

Contacts

Public ContactKumiko Ishida

Shinshu University School of Medicine Department of anesthesiology and resuscitrogy

kumiko_m@shinshu-u.ac.jp0263372670

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026