Ulcerative colitis
Conditions
Interventions
Oral administration of polyphosphate Step 1 300mg/day of polyphosphate, after meal in the mornig everyday for 28 days Step 2 1000mg/day of polyphosphate, after meal in the morning everyday for 28 da
Sponsors
Asahikawa Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with refractory ulcerative colitis (Mayo score, 3 to 8; rectal bleeding score, 1 or more; endoscopic subscore, 2 or more)
Exclusion criteria
Exclusion criteria: Patients with drug allergies, renal failure, liver dysfunction, malignancies, pregnancy, history of bowel surgery, infectious colitis, irritable bowel disease, hyperthyroidism or hyperphosphatemia Patients who are judged to be ineligible by the chief study conductor or doctor in charge
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency and grade of adverse events due to 4-week administration of polyphosphate for the treatment of ulcerative colitis | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy of 4-week administration of polyphosphate for improvements in clinical and histological inflammation and the expressions of pro-inflammatory cytokines in the treatment of ulcerative colitis | — |
Countries
Japan
Contacts
Public ContactMikihiro Fujiya
Asahikawa Medical University Division of Gastroenterology and Hematology/Oncology, Department of Medicine
Outcome results
None listed