A prospective comparative study of the sedation between a combination of propofol and dexmedetomidine hydrochloride and propofol alone in esophageal endoscopic submucosal dissection.

A prospective comparative study of the sedation between a combination of propofol and dexmedetomidine hydrochloride and propofol alone in esophageal endoscopic submucosal dissection. - Evaluation of the sedation with a combination of PF and DEX during esophageal ESD.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021487

Enrollment

Registered

2016-03-20

Start date

2016-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Superficial esophageal carcinomas or intraepithelial neoplasias scheduled for ESD.

Interventions

The sedation with a combination of propofol and dexmedetomidine hydrochloride. The sedation with propofol alone.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with superficial esophageal carcinomas and intraepithelial neoplasias scheduled for ESD.

Exclusion criteria

Exclusion criteria: Patients classified with an ASA physical status higher than II. Patients with a tracheotomy. Patients with any airway disorder. Patients with a cardiac pacemaker. Patients with gastric tube after esophageal surgery.

Design outcomes

Primary

Measure	Time frame
The occurrence of excess body movement during ESD.	—

Secondary

Measure	Time frame
ESD outcomes (including en bloc resection rate, complete resection rate and procedure times). The occurrence of procedure-related and sedation-related complication. The degree of satisfaction for ESD among physicians and assistants using a visual analog scale.	—

Countries

Japan

Contacts

Public ContactNonaka Takashi

Yokohama City University School of Medicine Department of Gastroenterology and Hepatology

nonaka_taka@yahoo.co.jp045-787-2640

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026