Urolithiasis
Conditions
Interventions
Standard treatment (Tiquijium bromide + dicrofenac)
Standard treatment +Tadarafil 2.5mg
Standard treatment +Tadarafil 5mg
Standard treatment +Tadarafil 10mg
Sponsors
Gunma University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Urolithiasis patients with its diameter of 6 mm or less. Patients should be 20 years-old or older. Written consent should be acquired from the patients.
Exclusion criteria
Exclusion criteria: 1) patients taking alpha1 receptor blocker 2) patients taking anti cholinergic agents 3) patients taking steroidal agents 4) pregnant women 5) patients with multiple ureteral stones 6) patients treated with NO donor 7) patients treated with Riociguat 8) patients with unstable angina, heart failure (over NYHA grade III), uncontrolled arrhythmia, hypotension (<90/50mmHg), uncontrolled hypertension (>170/100mmHg), cardiac infarction within last three months, cerebral hemorrhage /infarction with in last six months 9) patients with severe renal failure 10) patients with severe liver failure 11) patients cannot visit hospital for evaluation 12) others that decided inapplicable by principal investigator or sub-investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stone expulsive rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to stone expulsion, use of analgesia and adverse events. | — |
Countries
Japan
Contacts
Public ContactYasuhiro Shibata
Gunma University Hospital Urology
Outcome results
None listed