Comparison of the electroencephalogram under general anesthesia with sevoflurane and desflurane, from the point of bispectral index and 95% spectral edge frequency

Comparison of the electroencephalogram under general anesthesia with sevoflurane and desflurane, from the point of bispectral index and 95% spectral edge frequency - Comparison of the electroencephalogram under general anesthesia with desflurane and sevoflurane

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021448

Enrollment

120

Registered

2016-03-14

Start date

2016-03-14

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases requiring surgery

Interventions

To perform general anesthesia with desflurane at an end-tidal concentration of 1 minimum alveolar concentration (MAC) To perform general anesthesia with sevoflurane at an end-tidal concentration of 1

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing surgery under general anesthesia

Exclusion criteria

Exclusion criteria: Patients with (1) bronchial asthma, (2)arrhythmia, (3) psychiatric diseases or neuromuscular diseases, (4) ischemic heart diseases or decreased cardiac function with left ventricular ejection fraction equal to or less than 40%, (5) hypotension with systolic blood pressure equal to or less than 80 mmHg, (6) serum sodium levels equal to or less than 135 mEq/l; or equal to or more than 148 mEq/l

Design outcomes

Primary

Measure	Time frame
Bispectral index under general anesthesia with desflurane or sevoflurane at an end-tidal concentration of 1 MAC (minimum alveolar concentration), approximately 15-20 min following administration of desflurane or sevoflurane	—

Secondary

Measure	Time frame
Ninety-five % spectral edge frequency under general anesthesia with desflurane or sevoflurane at an end-tidal concentration of 1 MAC (minimum alveolar concentration)	—

Countries

Japan

Contacts

Public ContactYutaka Oda

Osaka City General Hospital Department of Anesthesiology

odayou@s5.dion.ne.jp06-6929-1221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026