Evaluation of plasma expansion effect of hydroxyethyl starch -Randomized comparison study between two different molecular sized drugs-

Evaluation of plasma expansion effect of hydroxyethyl starch -Randomized comparison study between two different molecular sized drugs- - Randomized comparison of plasma expansion effect between two different molecular sized HES drugs

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021385

Enrollment

Registered

2016-03-10

Start date

2016-03-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bilateral TKA planned patients under general anesthesia

Interventions

HES130/0.4 infusion group (starting from induction of general anesthesia) HES70/0.5 infusion group (starting from induction of general anesthesia)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients planned to have bilateral TKA operation under general anesthesia with using tourniquet

Exclusion criteria

Exclusion criteria: patients with severe complications tourniquet duration less than 30 minutes

Design outcomes

Primary

Measure	Time frame
hemodynamic stabilities at deflation of the tourniquet	—

Secondary

Measure	Time frame
changes of stroke volume variation (SVV) cumulated dose of used vasopressor drugs renal function(BUN,Cre)	—

Countries

Japan

Contacts

Public ContactHiroko Iwakiri

Tokyo Women's Medical University department of Anesthesiology

mkthrk@ff.em-net.jp03-3353-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026