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Effect of Eyewash Solution (Commercial washing solution) on the Corneal Epithelium: Adverse Effects of Benzalkonium Chloride on the Eye Surface

Effect of Eyewash Solution (Commercial washing solution) on the Corneal Epithelium: Adverse Effects of Benzalkonium Chloride on the Eye Surface - Effect of Eyewash Solution (Commercial washing solution) on the Corneal Epithelium

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000021319
Enrollment
30
Registered
2016-03-03
Start date
2013-11-13
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

allergic conjunctivitis

Interventions

Eyebon W Vitamin [Methods] The subjects washed the right eye with the physiological saline solution as the control and the left eye with the respective test solutions without anesthesia. The eyes we

Sponsors

Tsurumi University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: *Healthy individuals who had not used contact lenses for at least 1 day before the study. *Healthy individuals aged 20 years and older at the time of informed consent. *Healthy individuals that received a full explanation on the objectives and methods of the study, expected effects and adverse drug reactions, respect for the privacy, recompense and compensation, and who themselves or their legal representatives voluntarily provided consent for study participation.

Exclusion criteria

Exclusion criteria: Subject who the investigator considers ineligible for enrolment.

Design outcomes

Primary

MeasureTime frame
1.Observation of corneal epithelium disorders (1) Fluorescein vital staining (2) Fluorophotometry 2. Evaluation of corneal epithelial mucin layer (1) Lissamine green vital staining

Secondary

MeasureTime frame
Fluorescein staining (2microL) was performed and evaluated initially, by an ophthalmologist before eye washing. Eyes were washed with 20 mL of BSS-plus after 10 minutes to wash away the fluorescein stain solution and, 20 minutes later (30 minutes after fluorescein staining), fluorescein remaining on the cornea was measured using the fluorophotometry. Following this, evaluation by lissamine green staining (2microL) was performed. After eye washing, fluorescein staining evaluation, fluorophotometry measurements, and lissamine green staining evaluation were performed in the same manner as before eye washing, and the results were compared before and after eye washing.

Countries

Japan

Contacts

Public ContactHiroshi Fujishima

Tsurumi University Faculty of Dentistry

fujishima117@gmail.com045-580-8599

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026