The study of the predictive factors for response to Tolvaptan in Liver cirrhosis patients with water retention

The study of the predictive factors for response to Tolvaptan in Liver cirrhosis patients with water retention - The study of the predictive factors for response to Tolvaptan in Liver cirrhosis patients with water retention

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000021300

Enrollment

Registered

2016-03-03

Start date

2016-01-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver cirrhosis with refractory water retention

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Liver cirrhosis patients with refractory water retention despite undergoing the other diuretics

Exclusion criteria

Exclusion criteria: (1)The patients with allergy to Tolvaptan (2)The patients who is difficult to take Tolvaptan (3)The patients who is difficult to drink water (4)The anuric patients (5)Hypernatremia (6)The pregnant

Design outcomes

Primary

Measure	Time frame
The change of urinary aquaporin-2 before and after the administration of Tolvaptan	—

Secondary

Measure	Time frame
The change of urinary osomolality, body weight,urinary volume before and after the administration of Tolvaptan	—

Countries

Japan

Contacts

Public ContactMasato Nakai

Hokkaido University Graduate School of Medicine Gastroenterology and hepatology

mst-j45@med.hokudai.ac.jp0117161161

Outcome results