Effect of oral lactoferrin in dry eye disease

Effect of oral lactoferrin in dry eye disease - oral lactoferrin in dry eye

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021249

Enrollment

Registered

2016-03-01

Start date

2012-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dry eye disease

Interventions

oral lactoferrin (300mg/day) for 1 month no intervention

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Dry eye patients are selected by the definition made by Japanese dry eye society in 2006. 1. Ocular symptoms 2. Abnormality of tear film (Schirmer I < 5 mm or tear break up time <5 sec) 3. Fluorescein staining score>=3/9 Above 3 points need to be satisfied.

Exclusion criteria

Exclusion criteria: Patients who has severe ocular inflammation Patients who has systemic diseases Patients who cannot accept ocular examination Patients who had ocular surgery within 6 months Patients who had lacrimal plug treatment within 1 month Patients who usually use contact lens

Design outcomes

Primary

Measure	Time frame
ocular symptoms, dye staining in ocular surface, Schirmer test I after 1 month of oral lactoferrin	—

Secondary

Measure	Time frame
Visual acuity after 1 month of oral lactoferrin	—

Countries

Japan

Contacts

Public ContactTetsuya Kawakita

Keio University School of Medicine Ophthalmology

kawatetsu@gmail.com03-3353-1211

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026