Titanium allergy
Conditions
Interventions
Perform patch test to healthy person with titanium sulfate solution and titanimu chloride solution and oxidized titanium, it is judged according to the criteria of International Contact Dermatitis Res
Sponsors
Hiroshima University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Subjects who agree to participate for a week-long study. 2.Subjects who agree for a written informed consent for participating in this study. 3. Subjects without any symptoms of allergy (allergic dermatitis, palmoplantar pustulosis and lichen planus) and titanium allergy over the past decade.
Exclusion criteria
Exclusion criteria: 1. Subjects who cannot interrupt the anti-allergic drugs from 3 days before patch test to date ended. 2. Subjects who have used corticosteroid medicine internally and/or externally within 1 month prior to the study. 3. Pregnant women and women of child bearing potential. 4. Subjects who cannot give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive rate, negative rate, safety (rate of irritation response) and specificity to 0.1%, 0.5% titanium sulfate solution, 0.1% titanium chloride solution and oxidized titanium on the 7th day. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expression frequency and rate of adverse events | — |
Countries
Japan
Contacts
Public ContactMasae Kitagawa
Hiroshima University Hospital Center of Oral Clinical Examination
Outcome results
None listed