Prediction of outcomes and response to treatments with an ultrasensitive method for assessing intratumor epigenetic heterogeneity in colorectal cancer

Prediction of outcomes and response to treatments with an ultrasensitive method for assessing intratumor epigenetic heterogeneity in colorectal cancer - An ultrasensitive method for assessing intratumor epigenetic heterogeneity in colorectal cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000021191

Enrollment

Registered

2016-02-25

Start date

2016-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients are more than 20 and less than 80 years old 2.Patients without synchronous or metachronous multiple cancers 3.Eastern Cooperative Oncology Group performance status of 0, 1, or 2 4.Patients without severe complications (heart disease, liver disease, renal disease, infection) 5.All patients were required to give written informed consent prior to enrolment in the study

Exclusion criteria

Exclusion criteria: 1.Patients do not meet the inclusion criteria 2.Patients without histologically confirmed cancer 3.Patients whom investigators consider to be ineligible

Design outcomes

Primary

Measure	Time frame
The detection rates of epigenetic heterogeneity in primary tumor and plasma from colorectal cancer patients with Methylation-sensitive high resolution melt(MS-HRM).	—

Secondary

Measure	Time frame
1.To investigate the diffenrences in the detection rates between quantitative methylation specific PCR (qMSP) and MS-HRM 2.To investigate the correlations between epigenetic heterogeneity and gene expression in primary tumor from colorectal cancer patients	—

Countries

Japan

Contacts

Public ContactKiichi Sugimoto

Juntendo University Faculty of Medicine Department of Coloproctological Surgery

ksugimo@juntendo.ac.jp03-3813-3111

Outcome results