Natural initialcaries caries lesions remineralization by chewing sugar-free gum containing bio-available fluoride

Natural initialcaries caries lesions remineralization by chewing sugar-free gum containing bio-available fluoride - Initial caries lesions remineralization by chewing gum

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021135

Enrollment

Registered

2016-02-22

Start date

2014-09-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

initial caries lesion

Interventions

daily chewing gum containing bioaveialble calcium and fluoride over 3 months daily chewing gum containing bioaveialble fluoride over 3 months daily chewing placebo gum over 3 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: For inclusion in the study, the subjects were required to have at least one WSL, with an ICDAS score of 2 or 1

Exclusion criteria

Exclusion criteria: Exclusion criteria included smoking, evidence of poor oral health including periodontal disease, recent professional fluoride therapy (<2 weeks), uptake of fluoridated water or any medication that could affect oral flora, and pregnancy.

Design outcomes

Primary

Measure	Time frame
surface property of initial caries lesions are evaluated by ICDAS score	—

Secondary

Measure	Time frame
lesion depth of initial caries are evaluated using OCT images	—

Countries

Japan

Contacts

Public ContactKitasako Yuichi

Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Cariology and Operative Dentistry

kitasako.ope@tmd.ac.jp03-3813-6111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026