Efficacy and safety of administration of Tolvaptan twice daily in hospitalized acute heart failure patients

Efficacy and safety of administration of Tolvaptan twice daily in hospitalized acute heart failure patients - Administration of Tolvaptan twice daily in hospitalized acute heart failure patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021110

Enrollment

Registered

2016-02-19

Start date

2016-02-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute heart failure

Interventions

Administrations of Tolvaptan once daily at 9 AM (Duration of administration or total dose of Tolvaptan is determined by clinical course) Administrations of Tolvaptan twice daily at 9 AM and 3 PM (Dura

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hospitalized acute heart failure patients with volume overload Subjects with NYHA functional classification II-IV Subjects with Furosemide > 40mg/day Serum sodium level < 140mEq/L Agreement with written informed consent

Exclusion criteria

Exclusion criteria: Subjects with hemodialysis or anuria Subjects with acute coronary syndrome, pregnancy, malignancy, or previously administration of Tolvaptan

Design outcomes

Primary

Measure	Time frame
change of congestion scale (7 consecutive days from administration)	—

Secondary

Measure	Time frame
serial change of renal function (7 consecutive days after administration) urine volume (7 consecutive days after administration) weight change (7 consecutive days after administration) serial change of other laboratory markers(7 consecutive days after administration) prognosis(30-day, 6-month)	—

Countries

Japan

Contacts

Public ContactMitsutoshi Oguri

Kasugai Municipal Hospital Department of Cardiology

oguricap0909@gmail.com0568-57-0057

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026