Healthy volunteer
Conditions
Interventions
Ingestion of supplement containing, lutein, salmon nasal cartilage extract (containing proteoglycan and type 2 collagen) and N-acetyl glucosamine for 12 weeks
Ingestion of placebo without lutein, sa
Sponsors
HUMA R&D CORP
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Males and females aged from 30 to 74 years 2) Healthy subjects who feel pain of knee 3) Subject who is diagnosed KLgrade 0 or 1 4) Subject's score in the "pain, walking ability" of the JOA decision is less than 26 points
Exclusion criteria
Exclusion criteria: 1) Subjects receiving treatment for pain of knee 2) Subjects receiving drug treatment 3) Subject receiving treatment for hyperuricemia 4) Subject receiving treatment or having a medical history for serious disease such as diabetes, cardiovascular disease, liver disease, kidney disease and heart disease 5) Subjects having rheumatism 6) Subjects having surgery of the knee or those who need knee surgery 7) Subjects having drug treatment plan for joint, during the test period 8) Subjects who has carried out the intra-articular injection of hyaluronic acid within two weeks, or the intra-articular injection of steroids within three months prior to the start of the present study 9) Subject having a medical history for disease related to bone and joints, such as fracture or sprain within three months 10) Subject taking lutein, salmon cartilage extract, proteoglycan, type 2 collagen, N-acetyl glucosamine, and other health food (hyaluronic acid, glucosamine, chondroitin sulfate, etc.) that might affect the evaluation of the test 11) Subject taking pharmaceutical products(especially glucosamine, chondroitin sulfate, vitamin D, containing amino acid, the drug treatment of osteoporosis) 12) Subject using a cane, routinely 13) Subject taking warfarin 14) Subject presenting known allergy to food or drug 15) For female subject: pregnancy or breast feeding, or possibility of pregnancy, or intention to be pregnant during the study 16) Subject deemed unsuitable by the investigator or test sharing doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| JKOM and Knee Society Score(ver 2011) | — |
Countries
Japan
Contacts
Public ContactToshiki Kataoka
HUMA R&D CORP Business Promotion Division
Outcome results
None listed