Activation of TRPM8 with cooling and application of menthol can reduce propofol injection-induced pain

Activation of TRPM8 with cooling and application of menthol can reduce propofol injection-induced pain - Activation of TRPM8 with cooling and application of menthol can reduce propofol injection-induced pain

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021078

Enrollment

120

Registered

2016-02-17

Start date

2016-02-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The patient whowere scheduled for elective surgery under anesthesia in our hospital.

Interventions

In Group non-cooling, a cooling gel pad stored at room temperature was applied on the left side of forearm. In Group cooling, a cooling gel pad stored at 7 degree was applied on the left side of for

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Planned operation patient under the general anesthesia.

Exclusion criteria

Exclusion criteria: 1.Patients administered an analgesic before operation. 2.Patients have an allergy to propofol. 3.Patients have an allergy to ethanol. 4.Patients who have a skin disease to the arms.

Design outcomes

Primary

Measure	Time frame
During the injection of propofol,we assess the incidence and intensity of propofol injection-induced pain and a 4-point numerical rating scales.	—

Countries

Japan

Contacts

Public ContactMaiko Suzuki

Shinshu University Department of Anesthesiology and Resuscitology

mmw@shinshu-u.ac.jp0263-37-2670

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026