asthma
Conditions
Interventions
Add on tiotropium bromide(5 microgram/day).
Add on theophylline (400 mg/day).
Sponsors
Nagoya City University Dept of Respiratory Medicine, Allergy and Clinical Immunology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with chronic asthmatic cough lasting for 8 weeks or more despite adequate treatments including inhaled corticosteroids and long-acting adrenergic bronchodilator
Exclusion criteria
Exclusion criteria: If patients meet the following criteria, they are excluded. Patients who have other respiratory disease such as tuberculosis or lung cancer. currently smoke, had smoking history with 10 pack-years or more, or had quitted smoking within 6 months prior to the enrollment. have already taken anti-cholinergic agents or xanthin. have already taken some medicines with anti-cholinergic effects have allergy for anti-cholinergic agents or xanthin. have benign prostatic hypertrophy with dysuria. have closed-angle glaucoma. are during pregnancy or lactaion, or have possibility of pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the changes of the degree of cough severity and the cough-specific quality of life before and 4 weeks after the treatment intervention, with a use of Cough Visual Analogue Scale and Leicester Cough Questionnaire, respectively | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the changes of capsaicin cough reflex sensitivity and several biomarkers before and 4 weeks after the treatment intervention | — |
Countries
Japan
Contacts
Public ContactKensuke Fukumitsu
Nagoya City University Dept of Respiratory Medicine, Allergy and Clinical Immunology
Outcome results
None listed