Clinical study comparing the effect of Vonoprazan, on the healing of endoscopic submucosal dissection-derived artificial ulcer with PPI : a case controlled study.

Clinical study comparing the effect of Vonoprazan, on the healing of endoscopic submucosal dissection-derived artificial ulcer with PPI : a case controlled study. - Effect of Vonoprazan, on the healing of endoscopic submucosal dissection-derived artificial ulcer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000021010

Enrollment

Registered

2016-02-14

Start date

2014-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-ESD(endoscopic submucosal dissection) artificial gastric ulcer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The study subjects were 75 consecutive patients who treated by Vonoplazan (20mg /day, 5week) after endoscopic submucosal dissection(ESD) for early gastric neoplasm from April 2014 to February 2015 at our hospital. Control subjects were selected from among 870 patients who had treated by PPI(Rabeprazole 20mg/day, 8week) for artificial gastric ulcer after endoscopic submucosal dissection(ESD) from April 2005 to March 2014 at our hospital. Age-, sex-, the size of ulcer- and Helicobacter pylori infection-matched two control subjects were selected for one case subject(control group).

Exclusion criteria

Exclusion criteria: Patients who received additional chemotherapy or surgical treatment after endoscopic submucosal dissection(ESD) Patients who discontinued Vonoprazan due to side effects Remnant stomach

Design outcomes

Primary

Measure	Time frame
We assessed the rate of decrease in ulcer size and the postoperative bleeding rate	—

Countries

Japan

Contacts

Public ContactShigenao Ishikawa

Kagawa Prefectural Central Hospital Department of Gastroenterology

ishikawa5308@yahoo.co.jp087-811-3333

Outcome results