BRAF mutational status in Japanese patients with RAS wild-type metastatic colorectal cancer; a nation-wide multicenter observational study

BRAF mutational status in Japanese patients with RAS wild-type metastatic colorectal cancer; a nation-wide multicenter observational study - BRAF mutational status in Japanese patients with RAS wild-type metastatic colorectal cancer; a nation-wide multicenter observational study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000021002

Enrollment

1000

Registered

2016-03-15

Start date

2017-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metastatic colorectal adenocarcinoma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)The subject has histologically confirmed colorectal adenocarcinoma. 2)The subject has metastatic or locally advanced disease not amendable to curative surgery. 3)The subject must be currently receiving or prior to first-line chemotherapy. 4)The subject is at least 20 years of age at the time of informed consent. 5)The patient has provided singed informed consent prior to any study specific procedures.

Exclusion criteria

Exclusion criteria: 1)The subject has other malignancies which affect the patients' survival time. 2)The tumor has previously confirmed RAS mutant or BRAF mutant colorectal cancer. 3)The subject is receiving or panning to concomitant radiotherapy for primary site. 4)The subject is not appropriate for this study due to any other reasons.

Design outcomes

Primary

Measure	Time frame
Describe frequency of BRAF mutations (V600E and non-V600E mutations) in KRAS/NRAS wild-type metastatic colorectal adenocarcinoma.	—

Countries

Japan

Contacts

Public ContactHiroya Taniguchi

Aichi Cancer Center Hospital Department of Clinical Oncology

h.taniguchi@aichi-cc.jp052-762-6111

Outcome results