Development of hyperglycemic glucose clamp methods and evaluation of its outcomes in healthy subjects

Development of hyperglycemic glucose clamp methods and evaluation of its outcomes in healthy subjects - Development of hyperglycemic glucose clamp methods and evaluation of its outcomes in healthy subjects

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020958

Enrollment

Registered

2016-02-12

Start date

2016-02-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus

Interventions

Hyperglycemic glucose clamp technique. 120 minute clamp/ subject

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1, Healthy Japanese male subjects who provide signed written informed consent. 2, Subjects between 20 and 40 (inclusive) year of age at the time of consent. 3, Subjects with BMI <=18.5 and >25.0 at the time of screening. 4, Subjects with negative serological tests. 5, Subject judged as adequate for this study by study physician at screening.

Exclusion criteria

Exclusion criteria: 1, Subjects with present and/or past illness considered inadequate for this study. 2, Subjects with past history of drug allergy. 3, Subjects with history of caffeine, alcohol and/or drug abuse. 4, Subjects who was judged not appropriate for this study by study physician.

Design outcomes

Primary

Measure	Time frame
Evaluation of hyperglycemic glucose clamp technique. Evaluation of the parameters of the first- and second- insulin secretory ability, and the transitions of glucose, insulin and c-peptide	—

Secondary

Measure	Time frame
Safety by evaluating AEs, serum potassium, and VAS for pain.	—

Countries

Japan

Contacts

Public ContactHinako Uchimaru

SOUSEIKAI Hakata Clinic Planning & Coordination Dept

hinako-uchimaru@lta-med.com0922837701

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026