The enteral environment analysis using the human feces for the chronic liver disease and relative examination with the clinical data, multiple center study.

The enteral environment analysis using the human feces for the chronic liver disease and relative examination with the clinical data, multiple center study. - Chronic liver disease and enterobacteria

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000020917

Enrollment

500

Registered

2016-02-07

Start date

2016-02-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic liver disease (nonalcoholic steatohepatitis, nonalcoholic fatty liver disease), healthy volunteer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients who are diagnosed as follows: Chronic hepatitis patients, especially, NASH/NAFLD patients who are diagnosed based on the Medical treatment guide 2010 of NASH, NAFLD of Japanese liver society guidelines and healthy volunteer.

Exclusion criteria

Exclusion criteria: 1) Re-registration example to the examination 2) The patients with malignant tumor 3) In addition, the patient who judged an arrangement to the examination if the medical attendant was inappropriate 4) The patients that specimen collection is not possible by dyschezia.

Design outcomes

Primary

Measure	Time frame
Difference of bacterial flora between healthy volunteer and each chronic liver disease.	—

Secondary

Measure	Time frame
Difference of parameters as below between healthy volunteer and each chronic liver disease. Blood: endotoxin, metabolome(bile acid, organic acid, short chain fatty acid, amino acid etc.). Feces: metabolome (bile acid, organic acid, short chain fatty acid, amino acid etc.), mucin Urine: lactulose mannnitol ratio. Comparison of the above items with clinical findings.	—

Countries

Japan

Contacts

Public ContactKento Imajo

Yokohama city university Gastroentelorogy and hepatology

kento318@yokohama-cu.ac.jp045-787-2640

Outcome results