A treatment option for Medication-resistant depression
Conditions
Interventions
Left DLPFC intermittent TBS group (1 session/day, 5 days/week,2weeks)
80% active motor threshold, 1800 pulses once
Left DLPFC 10Hz rTMS group (1 session/day, 5 days/week,2weeks)
100% motor threshold,1600 pulses once
Sham group(1 session/day, 5 days/week,2weeks) randomly divided to half with TBS and half with rTMS parameters using a sham coil.
Sponsors
Taipei Veterans General Hospital, Taiwan
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: adult patients with the relapse of major depressive episode
Exclusion criteria
Exclusion criteria: Patients with schizophrenia, organic mental disorder and major physical illness; with brain implants or cardiac pacemakers; pregnancy; or who having strong suicidal risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the changing of HDRS-17 (week-2 vs. baseline) in response to the 2-week prefrontal brain stimulation | — |
Secondary
| Measure | Time frame |
|---|---|
| Computerized rACC-engaging cognitive tasj(RECT); EEG; Maudsley Staging method for refractoriness; response rate; the changing of HDRS-17 of the 12-week follow-up after the treatment (week-14 vs. baseline) in response to the 2-week brain stimulation; Young mania Rating scale; Clinical Global Index; Depression and somatic symptoms; Life stress scale; the comparison for localization between" 5 cm rule" and MRI neuro-navigation. | — |
Countries
Asia(except Japan)
Contacts
Public ContactCheng-Ta Li
Taipei Veterans General Hospital, Taiwan Psychiatry
Outcome results
None listed