Azoospermia
Conditions
Interventions
1)Oocyte collection for patient'
s wife is performed after ovarian stimulation. 2)Round spermatid injection into the oocyte is performed. 3) The number of examined oocytes is one when number of collected oocytes is less than 10, on
Sponsors
Saint Mother Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patients who had consented to participate in this treatment and satisfied the following conditions. 1. The round spermatid is their most advanced spermatogenic cell. 2. Testicular spermatozoa are dead, have head anomalies or the elongating and elongated spermatids are degenerative. 3. The number of collected oocytes from wives of patients that meet 1, 2 criteria is over five.
Exclusion criteria
Exclusion criteria: 1. In the case when even once a few spermatozoa have been found even if no spermatozoa are observed in other frequent analysis. 2. In the case when the possibility of obtaining round spermatids is near zero. 3. In the case when the surgical procedure for round spermatid collection is likely to deteriorate the patient's health. 4. In the case when the number of collected oocytes from patient's wife is less than five.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the pregnancy rate per cycles and miscarriage rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of preimplantation development Rate of PLCZ1 mRNA decay, Array CGH Methylation profile mRNA expression profile Birth rate | — |
Countries
Japan
Contacts
Public ContactAtsushi Tanaka
Saint Mother Hospital
Outcome results
None listed