The relationship between the cough response to bronchoconstriction induced by the methacholine provocation using the astographmethod and cough reflex sensitivity to inhaled capsaicin in healthy subjects

The relationship between the cough response to bronchoconstriction induced by the methacholine provocation using the astographmethod and cough reflex sensitivity to inhaled capsaicin in healthy subjects - The relationship between the cough response to bronchoconstriction induced by the methacholine provocation and cough reflex sensitivity to inhaled capsaicin in healthy subjects

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020804

Enrollment

Registered

2016-01-30

Start date

2016-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cough variant asthma

Interventions

day1 The measurement of cough response to bronchoconstriction induced by methacholine provocation using Astograph method day2 The measurement of cough reflex sensitivity to inhaled capsaicin day3 Th

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects with non-smoker, aged over 20 years were eligible for the study.

Exclusion criteria

Exclusion criteria: Subjects were excluded if they had a history of any clinically significant respiratory disorders, tachyarrhythmia, heart failure or disorder that might put them at risk or influence the study results or their ability to participate.

Design outcomes

Primary

Measure	Time frame
The cough number induced by the methacholine provocation and cough reflex sensitivity to inhaled capsaicin	—

Countries

Japan

Contacts

Public ContactJohsuke Hara

Kanazawa University Graduate School of Medicine Respiratory Medicine, Cellular Transplantation Biology

hara0728@gmail.com076-265-2000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026