Atopic disease
Conditions
Interventions
propolis From entry to blood sampling at 1 year, participants are asked to take propolis (302.4mg/day) for 2 to 10 months.
placebo From entry to blood sampling at 1 year, participants are asked to t
Sponsors
The Jikei University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Mother has atopic symptom; having or had at least one of asthma, atopic dermatitis, food allergy, allergic rhinitis or hay fever in medical inquiry. Not only medical judgment by physician, personal statement is also acceptable. 2) Breast feeding. Combination with artificial milk is also acceptable. 3) Infant is 2-8 month-old; exceptionally if the infant has been suffering before 8 months-old, entry is available till 10 month-old. 4) Infant has dermatitis (eczema, dry skin, etc.). It continuously or intermittently exists more than 1 month although intensive skin care such as soap at bath time is conducted on him/her without any medical anti-inflammatory treatment on local skin. If there is medical intervention, symptom less than 1 month is acceptable.
Exclusion criteria
Exclusion criteria: 1) Mother is under 20 year-old. 2) Infant has significant primary disease other than atopic disease. 3) Mother has allergy against; Wheat, propolis, honey, perilla oil,farina, geratin, glycerin, pectine, carrageenan, beeswax or lectin (from soybean) 4) Totally artificial milk feeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non-specific IgE is more than 10 IU/mL or antigen-specific IgE is more than 0.34 IU/mL in an infant when 1 year-old. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Atopic asthma bronchitis: Symptom of wheezing at medical inquiry and IgE against mites more than 0.34 IU/mL 2) Atopic dermatitis: Prescription of topical steroid during taking supplements | — |
Countries
Japan
Contacts
Public ContactGen Igarashi
The Jikei University School of Medicine Molecular Epidemiology
Outcome results
None listed