The investigation for the impact of preoperative physical and nutritional support on the muscle strength and muscle mass, and the incidence of postoperative complications following highly invasive surgeries.

The investigation for the impact of preoperative physical and nutritional support on the muscle strength and muscle mass, and the incidence of postoperative complications following highly invasive surgeries. - The impact of preoperative physical and nutritional support

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020780

Enrollment

Registered

2016-02-03

Start date

2016-02-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who are going to undergo major hepatectomy, pancreatoduodenectomy, subtotal esophagectomy, or total pelvic exenteration for cancer.

Interventions

Preoperative physical therapy Warming up, walking (30 min), resistance training (20 min), and cool down. Three to 7 times in a week. Nutritional therapy Oral intake of essential amino acids supple

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age equal to and over 20 years-old. Both gender. 2. Patients who are going to undergo either major hepatectomy, pancreatoduodenectomy, subtotal esophagectomy, or total pelvic exenteration for cancer. 3. Patients who agreed to participate in this study.

Exclusion criteria

Exclusion criteria: 1.Patients who are unable to do physical training. 2. Patients with metabolic dysfunction for amino acids. 3. Patients who are allergic to apple (because Amino L40 contains apple flavor). 4. A patient who by him-/herself or his/her family rejected to participate in this study. 5. A case of emergent surgery. 6. Patients with severe complications (heart disease, pulmonary disease, renal disease, hepatic disease, etc.). 7. Patients with severe mental dysfunction. 8. Patients with severe cognitive disorder. 9. Patients who were determined inappropriate to participate in this study by attending physician.

Design outcomes

Primary

Measure	Time frame
1. The impact of preoperative physical and nutritional therapy on the alternation of muscle mass, muscle strength, and functional capacity. Compare the data before and after (immediately before surgery, approximately 1.5 months after initiating therapy ) the induction of preoperative physical and nutritional therapy. 2. Difference in the incidence of postoperative complications (occurred within 1 month after surgery) between patients with preoperative physical and nutritional therapy and those without (case control study).	—

Measure

Time frame

1. The impact of preoperative physical and nutritional therapy on the alternation of muscle mass, muscle strength, and functional capacity. Compare the data before and after (immediately before surgery, approximately 1.5 months after initiating therapy ) the induction of preoperative physical and nutritional therapy. 2. Difference in the incidence of postoperative complications (occurred within 1 month after surgery) between patients with preoperative physical and nutritional therapy and those without (case control study).

—

Secondary

Measure	Time frame
1. The correlation between the preoperative muscle mass and muscle strength and the incidence of postoperative complications (occurred within 1 month after surgery). 2. The correlation between the muscle mass or muscle strength loss during the acute phase after surgery and the incidence of postoperative complications(occurred within 1 month after surgery).	—

Countries

Japan

Contacts

Public ContactYokoyama Yukihiro

Nagoya University Hospital Surgery 1

yyoko@med.nagoya-u.ac.jp+81527442222

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026