Major depressive disorder, Schizophrenia, Bipolar disorder
Conditions
Interventions
Desflurane is used for the first to 5th modified electroconvulsive therapy (mECT) session and Propofol is used for the 6th to 10 mECT session
Propofol is used for the first to 5th mECT session and Des
Sponsors
Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine, Osaka University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Inpatients at the University of Osaka Hospital whom are scheduled for modified electroconvulsive therapy (mECT) with the diagnosis for either major depression, schizophrenia, or bipolar disorder are asked to participate in the study. 2) Patients whom are over the age of 16 and are able to fully understand the terms and conditions of the study are eligible. 3) Patients whom have given informed consent to volunteer to enter this trial
Exclusion criteria
Exclusion criteria: 1) Patients unable to give informed consent to volunteer for this trial 2) When mECT is contraindicated Absolute contraindications: Known pheochromocytoma Relative contraindications: increased intracranial pressure, brain tumors, recent stroke, cardiovascular conduction defects, high-risk pregnancy, aortic and cerebral aneurysms, and Asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time for full recovery after modified electric convulsive therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcomes measured during each session 1) Heart rate, blood pressure, Bispectical Index during general anesthesia 2) Cumulative EEG duration, Visual seizure duration Outcomes measured at time points of the physician's discretion 1) PANSS 2) HAM-D 3) Global Assessment of Functioning 4) Clinical Global Impression of Change 5) Mini Mental State Examination | — |
Countries
Japan
Contacts
Public ContactSho C. Shibata
Graduate School of Medicine, Osaka University Department of Anesthesiology and Intensive Care Medicine
Outcome results
None listed