recessive dystrophic epidermolysis bullosa or junctional epidermolysis bullosa
Conditions
Interventions
transplanting of J-TEC-01 from revertant mosaicism to skin ulcer or erosion.
Sponsors
Hokkaido University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)patients diagnosed as severe recessive dystrophic epidermolysis bullosa or junctional epidermolysis bullosa (2)patients whose causative mutations are identified in COL7A1, COL17A1, LAMA3, LAMB3 or LAMC3. (3)patients who have one or more ulcers to be grafted with J-TEC-01 (4)patients who clinically have skin area with revertant mosaicism resistant to mechanical stimuli. (5)patients who have competence and from which we can obtain document consent (6)20 years of age or older
Exclusion criteria
Exclusion criteria: (1)patients who have allergy to particular antibiotics (Penicillin, Kanamycin, Amphotericin B) . (2)patients who have allergy to caw, mouse or pig. (3)patients who participate in other clinical trials within 6 month. (4)patients who have malignant tumor or past history of malignancy within 3years (except cutaneous malignancy). (5)those who are pregnant or nursing mum, or patients who are planning pregnancy during the study. (6)patients whom the investigators judge inappropriate as a subject for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the individual rate of epithelialization (%) at 4 week after the graft | — |
Countries
Japan
Contacts
Public ContactYasuyuki Fujita
Hokkaido University Graduate School of Medicine Department of Dermatology
Outcome results
None listed