The relationship between anti-Xa activity and the renal function in elderly patients who are on apixaban

The relationship between anti-Xa activity and the renal function in elderly patients who are on apixaban - The relationship between anti-Xa activity and the renal function in elderly patients who are on apixaban

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000020692

Enrollment

100

Registered

2016-04-01

Start date

2016-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrial fibrillation

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 70 years or older who are on apixaban for the prevention of ischemic strokes and systemic embolisms in patients with nonvalvular AF

Exclusion criteria

Exclusion criteria: Patients contraindicated for apixaban (1)Patients with a history of a hypersensitivity to the ingredients of apixaban (2)Patients with bleeding symptoms which can be of a clinical concern within 6 months (e.g., active gastric ulcers, platelets < 100000, hemoglobin < 10 g/dL, and s stroke within 10 days) (3)Patients with blood clotting defects and liver disease with a clinically important bleeding risk (4)Patients with renal failure (creatinine clearance < 15 mL/min) Severe liver dysfunction (AST and ALT of > 2-fold the upper limits of normal (ULN) and a total bilirubin of > 1.5-fold the ULN) Patients with valvular disorders requiring surgery Patients who cannot orally take drugs or visit the Outpatient Unit on a regular basis Patients with a prognosis of < one year Patients anticoagulated with heparin or enoxaparin

Design outcomes

Primary

Measure	Time frame
The confounding factors for affecting the anti-Xa activity and serum concentration.	—

Countries

Japan

Contacts

Public ContactTakehiro Kimura

Keio University School of Medicine Department of Cardiology

kimura@z7.keio.jp0333531211

Outcome results