Effectiveness of honey and expectorant for nocturnal cough in children with acute upper respiratory infection : a prospective interventional study

Effectiveness of honey and expectorant for nocturnal cough in children with acute upper respiratory infection : a prospective interventional study - Effectiveness of honey for nocturnal cough in children: a prospective interventional study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020651

Enrollment

Registered

2016-01-25

Start date

2016-01-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute upper respiratory infection in children

Interventions

Honey Group: Patients in this group take honey (5g for 2-5y, 10g for 6y-) prior to bedtime orally for a week. Expectorant Group: Patients in this group take expectorants (eg. Carbocisteine 30mg/kg/

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patient diagnosed with acute upper respiratory infection with cough for 7 or fewer days duration. 2) nocturnal cough score 3 or more (using a 7point Likert scale)

Exclusion criteria

Exclusion criteria: 1) Following medications had been given for patient on the day before or after :Antihistamines, beta2agonists, Steroids, Leukotriene receptor antagonists eg) asthma, atopic dermatitis, allergic rhinitis 2) Patient admitted to hospital 3) Patient with underlying disease eg) Cerebral palsy, Congenital heart disease, Chronic lung disease, Myopathy, Malformation syndrome, Immunodeficiency

Design outcomes

Primary

Measure	Time frame
Change in frequency of nocturnal cough on the next day when honey or expectorant had been given prior to bedtime compared to that on the first day of presentation when no medication had been given.	—

Secondary

Measure	Time frame
Change in severity of nocturnal cough, bothersome cough, appetite and quality of sleep at night on the next day when honey or expectorant had been given prior to bedtime compared to that on the first day of presentation when no medication had been given. Improvement of nocturnal cough one week after when honey or expectorant had been given prior to bedtime compared to that on the first day of presentation when no medication had been given.	—

Measure

Time frame

Change in severity of nocturnal cough, bothersome cough, appetite and quality of sleep at night on the next day when honey or expectorant had been given prior to bedtime compared to that on the first day of presentation when no medication had been given. Improvement of nocturnal cough one week after when honey or expectorant had been given prior to bedtime compared to that on the first day of presentation when no medication had been given.

—

Countries

Japan

Contacts

Public ContactShun Kishibe

Tokyo Metropolitan Children's Medical Center Pediatric Emergency Medicine

jemstone625@gmail.com042-300-5111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026