Effect of transcranial direct current stimulation on the dopamine-GABA systems in healthy subjects

Effect of transcranial direct current stimulation on the dopamine-GABA systems in healthy subjects - Effect of tDCS on the dopamine-GABA systems in healthy subjects

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020583

Enrollment

Registered

2016-03-01

Start date

2016-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

psychiatric and neurological disease

Interventions

Anodal and cathodal electrodes are placed at the left frontal areas and right frontal areas, respectively. 13-min tDCS with a current intensity of 2 mA is applied twice with a 20-min. After more than

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1.Healthy right-handed man over twenty years of age 2.With intelligence score IQ>80 on the Japanese Adult Reading Test 3.People who have consent to participate in this research

Exclusion criteria

Exclusion criteria: 1.People with a history of traumatic brain injury and a episode of an unconsciousness lasting more than 5 minutes 2.People with a history of organic brain diseases 3.People with a history of seizure 4.People with chronic headache 5.People who cannot undergo an MRI scan

Design outcomes

Primary

Measure	Time frame
Analyze changes in binding potential of [11C]raclopride in PET and GABA levels in MRS between tDCS and sham stimulation conditions.	—

Secondary

Measure	Time frame
Analyze changes of cognitive test scores between tDCS and sham stimulation conditions.	—

Countries

Japan

Contacts

Public Contactbunai tomoyasu

Hamamatsu University School of Medicine Department of Biofunctional Imaging

bunai.t@hama-med.ac.jp053-435-2466

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026