hepatocellular carcinoma
Conditions
Interventions
None listed
Sponsors
Gunma University Heavy Ion Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) pathollogically or clinically diagnosed hepatocellular carcinoma. 2) Satellite nodules (daughter nodules) and/or tumor thrombus are contiguous or adjacent to the main tumor. 3) Tumor is measurable and tumor size is 10 cm or less than 10 cm. 4) Absence of invasion to the main branch of portal vein, common hepatic duct, or inferior vena cava. 5) cN0M0 (accrdiong to UICC(International Union Against Cancer) TMN classification of Malignant tumours 7th edition) 6) At least 4 weeks passed after the previous therapy of hepatectomy, local ablation therapy or TACE. 7) No other intrahepatic lesion or at least 2 years passed after the previous curative therapy to other intraheaptic lesions. 8) Perfomance status of the patient is from 0 to 2. 9) Child-Pugh score of the patient is from 5 points to 9 points. 10) The patient is able to understand the explanation of the clinical trial and written informed concent is obtained.
Exclusion criteria
Exclusion criteria: 1) History of radiation therapy to the lesion of interest. 2) The alimentary tract was adjacent to the target lesion. 3) Patients with any other active malignancies. 4) Patient with severe comorbidity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-year local control rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival Progression free survival Response rate Acute toxicity(within 6 months) Late toxicity(6 months or later) | — |
Countries
Japan
Contacts
Public ContactTatsuya Ohno
Gunma University Heavy Ion Medical Center
Outcome results
None listed