Fibrosis in Childhood Interstitial Lung Diseases: Correlation with Clinical Characteristics

Fibrosis in Childhood Interstitial Lung Diseases: Correlation with Clinical Characteristics - Fibrosis in Childhood Interstitial Lung Diseases

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020542

Enrollment

Registered

2016-01-15

Start date

2012-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood Interstitial Lung Diseases

Interventions

markers of fibrosis

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: chILD diagnostic criteria were at least three of following criteria: (1) respiratory symptoms (e.g., cough, rapid and/or difficult breathing, or exercise intolerance); (2) respiratory signs (e.g., resting tachypnea, adventitious sounds, retractions, digital clubbing, failure to thrive, or respiratory failure); (3) hypoxemia; (4) diffuse abnormalities on chest X-ray (CXR) or high resultion computed tomography (HRCT).

Exclusion criteria

Exclusion criteria: Patients were excluded from this study if they hadbronchopulmonary dysplasia, congenital heart disease, primary or acquired immunodeficiency, primary autoimmune disorder, cystic fibrosis or pulmonary tuberculosis.

Design outcomes

Primary

Measure	Time frame
Markers of fibrosis (TGF-beta1, sFas, CCN2) and elastin destruction (UDes/UCr) were increased in chILD. So blockage of their pathways signals may offer novel therapeutic targets.	—

Countries

Africa

Contacts

Public ContactKhaled Saad

Faculty of medicine, University of Assiut, Assiut 71516, Egypt. Faculty of medicine

med@aun.edu.eg+20882368373

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026