Upper tract urothelial carcinoma
Conditions
Interventions
Intervention Group: In addition to standard open or laparoscopic radical nephroureterectomy, regional lymphadenectomy of the area defined as follows will be performed. Left: Left side of the para-ao
Sponsors
Department of Urology, Akita University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who meet the criteria as described below will be included: 1.Are presenting with an upper tract urothelial carcinoma located in the renal pelvis or ureter proximal to the lower renal pole level without lymph node metastasis that is diagnosed using CT scan and cytology. 2.Are presenting with a curable disease by radical nephroureterectomy. 3.Are presenting with no lymph-node swelling treated by the neo-adjuvant chemotherapies and is diagnosed to be a curable disease by radical nephroureterectomy. 4.Are presenting with an initial diagnosis of urothelial carcinoma. 5.Are presenting with ECOG performance status 0-1. 6.Agree with the protocol with signed informed consent
Exclusion criteria
Exclusion criteria: Patients who meet the criteria below will be excluded: 1.Are presenting with cTa or cTis tumor. 2.Are presenting with an upper tract urothelial carcinomas located in the ureter distal to the lower renal pole level. 3.Are presenting with cN1 or cN2 disease and lymphadenectomy is strongly recommended. 4.Are presenting with distant metastases. 5.Have histories bladder cancer or have simultaneous bladder cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5-year recurrence-free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-year overall survival, 5-year cancer-specific survival, location of recurrences, perioperative complications | — |
Countries
Japan
Contacts
Public ContactShintaro Narita
Akita University Graduate School of Medicine Urology
Outcome results
None listed