chronic periodontitis
Conditions
Interventions
minocycline ointment duration of administration 1time/week,for 4 weeks. dosage 0.5g/time
saline solution duration of administration 1time/week,for 4 weeks. dosage 0.5g/time
Sponsors
Kyushu university hospital
Kanagawa Dental University Hospital, Niigata University Medical &
Dental Hospital, Health Sciences University of Hokkaido Hospital, Hiroshimda University Hospital, Tokyo Medical And Dental University Hospital, Osaka University Dental Hospital, Okayama University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: *Age over40 years old *The patients who have more than 10 teeth. *The patients who have 4mm or more of periodontal pockets more than 30% per oral. *Document consnt has been obtrained for perticipation in this study.
Exclusion criteria
Exclusion criteria: *The patients who take medicine that make gingival hyperplagia. (cyclosporine, calcium blocker, phenitoin) *body mass index BMI over 30kg/m2 *The patients who has acute periodontitis at the initial visit or during this study period. *The patients who take immunosuppressive drugs, e.g. MTX,cyclosporine and anti-TNF therapy. *past and current smoker *more than class3 tooth moobility. *The patients who visited dental clinic within the past 6 months. *The patients who took antibiotics within the past 2 months. *pregnant female *Subjects who are judged as unsuitable for the study by the investigator for other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| periodontal pocket depth time of assesment after 4 weeks and 8 weeks from the start of the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| number of porphyromonas gingibalis inside periodontal pockets, bleeding on probing, attachment loss, hs-CRP | — |
Countries
Japan
Contacts
Public ContactAkiko Yamashita
Kyushu uuniversity periodontics
Outcome results
None listed