The multicenter study to examine microsatellite instability (MSI) in advanced gastrointestinal and abdominal malignant tumor

The multicenter study to examine microsatellite instability (MSI) in advanced gastrointestinal and abdominal malignant tumor - The multicenter study to examine MSI in advanced gastrointestinal and abdominal malignant tumor (GI-SCREEN MSI)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000020437

Enrollment

3500

Registered

2016-01-05

Start date

2016-01-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastrointestinal and abdominal malignant tumor

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with histologically confirmed or clinically suspected advanced gastrointestinal or abdominal malignant tumor a: Colorectal cancer b: Gastric cancer c: Esophageal cancer d: Hepatocellular carcinoma e: Biliary tract cancer f: Pancreatic cancer g: Small intestine, Appendix or Anal canal cancer h: Neuroendocrine tumor or cancer of GI i: Gastrointestinal stromal tumor 2) Planned to receive systemic chemotherapy for malignant tumor 3) Presence or ability to acquire sufficient samples for MSI and/or MMR-IHC testing 4) Written informed consent was obtained

Exclusion criteria

Exclusion criteria: 1) Judged by the investigator to be inappropriate for study participation for any reason

Design outcomes

Primary

Measure	Time frame
The frequency of MSI-H in advanced gastrointestinal and abdominal malignant tumor	—

Secondary

Measure	Time frame
Association between MSI and MMR-IHC status and cancer genome alterations, molecular biological characteristics, clinicopathological features or prognosis	—

Countries

Japan

Contacts

Public ContactWataru Okamoto

National Cancer Center Hospital East Clinical Research Support Office

crc_msi_office@east.ncc.go.jp04-7133-1111

Outcome results