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Measurement of Cough Response to Bronchoconstriction Induced by Methacholine: An Examination Using the Astograph Method

Measurement of Cough Response to Bronchoconstriction Induced by Methacholine: An Examination Using the Astograph Method - Cough Response to Bronchoconstriction induced by Methacholine using the Astograph Method

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000020430
Enrollment
40
Registered
2016-01-04
Start date
2014-09-25
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cough variant asthma

Interventions

day1 The measurement of cough response to bronchoconstriction induced by Methacholine using original method day2 The measurement of cough response to bronchoconstriction induced by Methacholine using
Tokyo, Japan), according to the method of Takishima et al. Briefly, respiratory resistance was measured by the forced oscillation method (3 Hz) during continuous inhalation of Methacholine in stepwise
1min before, and for 30 min following inhalation of Methacholine at which Rrs and FEV1were archived.

Sponsors

Kanazawa University Graduate School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Subjects with non-smoker, aged 20 to 29 years were eligible for the study.

Exclusion criteria

Exclusion criteria: Subjects were excluded if they had a history of bronchial asthma, any clinically significant respiratory disorders, tachyarrhythmia, heart failure or disorder that might put them at risk or influence the study results or their ability to participate.

Design outcomes

Primary

MeasureTime frame
The total number of cough induced by two methods

Countries

Japan

Contacts

Public ContactJohsuke hara

Kanazawa University Graduate School of Medicine Respiratory Medicine, Cellular Transplantation Biology

hara0728@gmail.com076-265-2000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026