Study of additive effect of citrus juice fermented with lactic bacteria to sublingual immunotherapy for Japanese cedar pollinosis (Randomized placebo controlled double blind clinical study)

Study of additive effect of citrus juice fermented with lactic bacteria to sublingual immunotherapy for Japanese cedar pollinosis (Randomized placebo controlled double blind clinical study) - Study of additive effect of citrus juice fermented with lactic bacteria to sublingual immunotherapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020420

Enrollment

100

Registered

2016-01-03

Start date

2016-01-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Japanese cedar pollinosis

Interventions

Taking 125ml of citrus juice fermented with lactic bacteria (YIT0132) every day for 3 month around cedar pollen scattering period. Taking 125ml of placebo every day for 3 month around cedar pollen sca

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with Japanese cedar pollinosis who is being treated with sublingual immunotherapy

Exclusion criteria

Exclusion criteria: 1) Allergy to the intervention drink or citrus juice 2) Diabetes mellitus (HbA1c more than 6.0) 3) Pregnant women and those at risk of pregnancy 4) Women who are planning pregnancy 5) Lactating woman 6) Patients treated with anti-allergic drugs within 2 week of screening 7) The patients who the doctor judged inappropriate for the study 8) Severe asthma 9) Malignant disease or immune disorder

Design outcomes

Primary

Measure	Time frame
Comparison of the total nosal symptom medication score converted from a nasal allergy diary in peak of cedar pollen scattering	—

Countries

Japan

Contacts

Public ContactSyuji Yonekura

Chiba University Graduate School Department of Otorhinolaryngology

syonekura@faculty.chiba-u.jp043-222-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026