Nighttime heart rate changes after pacemaker implantation and the change of autonomic nervous activity, blood pressure circadian variation and marker of heart failure in patients with sick sinus syndrome

Nighttime heart rate changes after pacemaker implantation and the change of autonomic nervous activity, blood pressure circadian variation and marker of heart failure in patients with sick sinus syndrome - Study of pacemaker settings, heart rate and circadian blood pressure change

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020373

Enrollment

Registered

2016-01-01

Start date

2016-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sick sinus syndrome

Interventions

Group A: [0 to 6 months] Lower rate limits of 60 beats per minute in daytime, 50 beats per minute in nighttime. [6 to 12 months] Lower rate limits of 60 beats per minute in daytime and nighttime.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients who are implanted DDD pace maker for their symptomatic sick sinus syndrome. (2) NTProBNP >=55. (3) Male or female, age 20 to 84 years. (4) Patients with written informed consent.

Exclusion criteria

Exclusion criteria: (1)Less than 1 month since onset of myocardial infarction, unstable angina or peripheral artery disease. (2) Patients with systemic embolism, or less than 3 month since onset of stroke. (3) Patients with malignant tumor (no improvement in symptoms). (4) Life expectancy of less than one year due to other pre-existing diseases. (4) Patients judged as unsuitable for the study by study investigators.

Design outcomes

Primary

Measure	Time frame
Improvement of NT-ProBNP, changes in blood catecholamine concentration at 6 and 12 months after the intervention.	—

Countries

Japan

Contacts

Public ContactTomoyuki Kabutoya

Jichi Medical University School of Medicine Division of Cardiovascular Medicine, Department of Medicine

kabu@jichi.ac.jp0285-58-7344

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026