None (Healthy adults)
Conditions
Interventions
Lactic acid bacteria, 1 portion of food per day for 13 days.
Placebo (not containing lactic acid bacteria), 1 portion of food per day for 13 days.
Sponsors
Juntendo University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Males and females aged more than 20 years old, when giving the informed consent. 2)Individuals who have daily exercise. 3)Individuals who are received enough explanation of the purpose and the details of this study, who are decided to attend this study with their own will, who have ability of agreement, and who submit the informed consents in writing.
Exclusion criteria
Exclusion criteria: 1)Individuals who can't stop drinking for 2 days before the days of screening and checkup. 2)Individuals who can't stop eating foods containing lactic acid bacteria and/or oligosaccharide, fermented foods during this study. 3)Individuals who can't stop eating functional foods which may affect immune functions. 4)Individuals who have a history of irritable bowel syndrome and Crohn's disease. 5) Individuals who have a medical history of serious disease (e.g., diabetes, liver disease, kidney disease, and/or heart disease), thyroid gland disease, adrenal gland disease, and/or metabolic disorder. 6)Individuals who have chronic diseases and use medicines continuously. 7)Individuals who have under treatment or a history of drug addiction and/or alcoholism. 8)Individuals who are judged as unsuitable for this study based on the results of blood test. 9)Individuals with excessive alcohol-drinking behaviors. 10)Individuals who have a medical history of diseases affecting digestion and absorption. 11)Individuals who are pregnant, breastfeeding, or planning to be pregnant in the near future. 12)Individuals who are participating or willing to participate in other clinical trials. 13)Individuals whose family works for a company manufacturing or selling healthy foods or functional foods. 14)Individuals with steroid treatment. 15)Individuals who are seropositive against HBV antigen, HCV antibody, HIV antibody, or HTLV-1 antibody. 16)Individuals who are judged unsuitable for this study by the investigator for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activities of dendritic cells and the immune-reaction of peripheral blood mononuclear cells to the stimulation of inactivated viruses (interferon-alpha production, and anti-viral genes expression), conditioning questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Immune activity, stress hormone amount, and cytokine amount of blood, salivary immune activity and stress hormone amount, conditioning questionnaire. | — |
Countries
Japan
Contacts
Public ContactKazunori Shimada
Juntendo University Graduate School of Medicine Department of Cardiovascular Medicine
Outcome results
None listed