None (Healthy adults)
Conditions
Interventions
Lactic acid bacteria, 1 portion of food per day for 4 weeks.
Placebo (not containing lactic acid bacteria), 1 portion of food per day for 4 weeks.
Sponsors
KSO Corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Males and females aged from 20 to less than 65 years old, when giving the informed consent. 2)Individuals who have low activities of immune cells in peripheral blood. 3)Individuals who give the informed consents in writing, after receiving enough explanation of the purpose and details of the study, understanding the study well, and deciding to attend the study with their own will.
Exclusion criteria
Exclusion criteria: 1)Individuals who can't stop drinking for 2 days until the screening and each checkup. 2)Individuals who can't stop eating foods containing lactic acid bacteria and oligosaccharide during this study. 3)Individuals who can't stop eating foods which may activate immune functions. 4)Individuals who have tendency to get diarrhea by eating dairy product. 5)Individuals who have a history of irritable bowel syndrome and Crohn's disease. 6)Individuals who was vaccinated and who may receive it this year. 7)Individuals who have a medical history of serious disease (e.g., diabetes, liver disease, kidney disease, and/or heart disease), thyroid gland disease, adrenal gland disease, and/or metabolic disorder. 8)Individuals who have chronic diseases and use medicines continuously. 9)Individuals who have under treatment or a history of drug addiction and/or alcoholism. 10)Individuals who are judged as unsuitable for the study based on the results of blood test. 11)Individuals with excessive alcohol-drinking behaviors. 12)Individuals who have a medical history of diseases affecting digestion and absorption. 13)Individuals who have a medical history of hay fever. 14)Individuals having food allergy. 15)Individuals who are pregnant, breastfeeding, or planning to be pregnant in the near future. 16)Individuals who are participating or willing to participate in other clinical trials or in the last 3 months. 17)Individuals who and whose family work for a company manufacturing or selling healthy foods or functional foods. 18)Individuals who are judged unsuitable for this study by the investigator for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of cytokines production and expression levels of anti-viral genes of peripheral blood mononuclear cells stimulated by viruses at 4 weeks after intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Activities of dendritic cells in peripheral blood at 4 weeks after intervention. (Cell surface expression levels of dendritic cells makers.) | — |
Countries
Japan
Contacts
Public ContactEiji Yoshikawa
KSO Corporation Sales department
Outcome results
None listed