Evaluation of drug interactions of cytochrome P450 by single-substrate administrations and the cocktail method

Evaluation of drug interactions of cytochrome P450 by single-substrate administrations and the cocktail method - Evaluation of drug interactions of cytochrome P450 by single-substrate administrations and the cocktail method

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020286

Enrollment

Registered

2015-12-21

Start date

2015-12-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

drug interaction

Interventions

drugs(CYP inducer and inhibitor) inducer : rifampicin 450 mg s.i.d for 6 days before trial inhibitor : cimetidine 400mg b.i.d for 2 days before trial, fluvoxamine 25 mg b.i.d for 2days before tr

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1 helthy male, over 20 years old 2 without hepatic disorder, renal disorder and disease under treatment 3 without medication allergy and idiosyncrasy 4 without drug dependence and alchol dependence 5 with consent to take part in this study by document

Exclusion criteria

Exclusion criteria: 1 being unwellness 2 with abnormalities of bllod examination in advance 3 inadequateness to this study

Design outcomes

Primary

Measure	Time frame
Pharmacokinetics of caffeine, losartan omeprazole, dextromethorphan	—

Countries

Japan

Contacts

Public ContactAkio Hakamata

Hamamatsu University School of Medicine Department of Clinical Pharmacology and Therapetics

hakamata@hama-med.ac.jp053-435-2385

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026