patients who were scheduled to undergo esophagectomy for esophageal cancer
Conditions
Interventions
Landiolol is infused continuously at 5 mcg/kg/min from before the surgery for 48 hours.
Saline is infused continuously from before surgery for 48 hours.
Sponsors
Akita University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ASA physical status 1 or 2 patients who were scheduled to undergo esophagectomy for esophageal cancer at Akita University Hospital were enrolled.
Exclusion criteria
Exclusion criteria: Patients with a history of cardiac (eg, atrial fibrillation, conduction abnormalities, arrhythmias, antiarrhythmic medication including beta-blockers, recent angina pectoris, myocardial infarction), pulmonary, or renal disease, thyroid dysfunction were excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidences of tachycardia (100>bpm) or arterial fibrillation during 48 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| plasma concentrations of cytokines (IL-1beta, IL-6, IL-8, IL-10, TNF-alpha) after the induction of anesthesia, after the surgery, the 1st postoperative day (POD), and 2nd POD | — |
Countries
Japan
Contacts
Public ContactToru Goyagi
Akita University Graduate School of Medicine Anesthesiology and Intensive Care Medicine
Outcome results
None listed