Healthy adults
Conditions
Interventions
Ingestion of 35g of paste made from "
Kishu plum treated with superheated steam"
daily for 12 weeks.
Ingestion of 35g of "
pickled plum"
paste daily for 12 weeks.
Sponsors
Hokkaido Information University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects whose arteriosclerosis index is >=1.5. 2. Subjects who agree to participate in the current study with a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects who are under treatmentand medication for hyperlipidemia and diabetes. 2. Subjects with familial hypercholesterolemia. 3. Subjects whose LDL-C is >=180 mg/dl. 4. Subjects with serious cerebrovascular, cardiac, hepatic, renal, gastrointestinal diseases, disorder of endocrine and metabolism or affected with infectious diseases which are required to report to the authorities. 5. Subjects who have a major surgical history related to digestive system such as gastrectomy, gastrorrhaphy, enterectomy, etc. 6. Subjects with unusually high and/or low blood pressure or abnormal hematological data. 7. Subjects with serious anemia. 8. Pre- or post-menopausal women having obvious changes in physical condition. 9. Subjects who are at risk of having allergic reactions to drugs or foods (especially plum and agar). 10. Subjects who regularly take drugs, functional foods and/or supplements (EPA, DHA, MCT, phytosterol, sesamin, turmeric, polyphenols, dietary fiber, etc.) which would affect the blood lipid levels. 11. Subjects who regularly take drugs, functional foods and/or supplements (containing dietary fiber such as indigestible dextrin, polyphenol, etc.) which would affect blood glucose. 12. Heavy smokers, alcohol addicts or subjects with irregular lifestyle 13. Subjects who donate either 400ml whole blood within 12 weeks or 200ml whole blood within 4 weeks or blood components within 2 weeks prior to this study. 14. Pregnant or lactating women or women expect to be pregnant during the clinical trial. 15. Subjects who participate in other clinical trials within the last one month prior to this study. 16. Any other medical reasons judged by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arteriosclerosis Index, TC, LDL-C, HDL-C and TG at 4, 8 and 12 weeks after the beginning of ingestion of test meals. | — |
Secondary
| Measure | Time frame |
|---|---|
| oxo-LDL, TBARS, VAS questionnaire for lassitude and defecation, frequency of bowel movement, body composition (BW, BFR, BMI) | — |
Countries
Japan
Contacts
Public ContactDir. Prof. Jun NISHIHIRA, M.D., Ph.D.
Hokkaido Information University Center of Health Information Science
Outcome results
None listed