Prospective multicenter trial for efficacy of potassium competitive acid blocker to reduce delayed bleeding after gastric endoscopic submucosal dissection in patients on antithrombotic therapy

Prospective multicenter trial for efficacy of potassium competitive acid blocker to reduce delayed bleeding after gastric endoscopic submucosal dissection in patients on antithrombotic therapy - Preventive effect of P-CAB for postoperative bleeding after gastric ESD

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000020174

Enrollment

Registered

2015-12-11

Start date

2015-12-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric neoplasm

Interventions

Daily use of Vonoplazan (day 1 - 28)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Diagnosis of gastric adenoma or early gastric cancer satisfying the Japanese guideline criteria. 2. On antithrombotic therapy 3. 20 years or older 4. Performance status (ECOG) is 0, 1 or 2 5. With a written informed consent.

Exclusion criteria

Exclusion criteria: 1. History of gastrectomy 2. Schedule of endoscopic treatment for esophageal or duodenal lesion concurrently. 3. History of endoscopic treatment for upper GI lesion in the past 28 days. 4. Schedule of endoscopic treatment for upper GI lesion within 28 days after the gastric ESD. 5. Systemic administration (intravenously or orally) of either one or more drugs of corticosteroid, anticoagulant agent. 6. Diagnosis of psychiatric diseases. 7. With active bacterial or fungus infection. 8. With uncontrollable hypertension. 9. Disqualified for the study by physicians.

Design outcomes

Primary

Measure	Time frame
Post-ESD bleeding rate	—

Countries

Japan

Contacts

Public ContactYoshito Hayashi

Osaka university graduate school of medicine Gastroenterology and hepatology

y.hayashi@gh.med.osaka-u.ac.jp06-6879-5111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026