Severe asthma
Conditions
Interventions
None listed
Sponsors
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients aged over 12 years old at index date. 2. Patients with medical records at Respiratory department at Kyoto University Hospital. 3. Patients with at least one record for asthma as defined by ICD-10 codes (J45) at Baseline period 4. Patients prescribed high-dose ICS as defined by JGL (2012) and at least one non-ICS controller for equal or more than 240 days at Baseline period.
Exclusion criteria
Exclusion criteria: 1. No treatment record of asthma as defined by ICD-10 codes (J45) in any of the following periods in order to secure two-years observation during the Baseline and Follow-up period. Given the prescription days at one visit is 120 days, at least one record of asthma will be required within 5 months of pre-baseline, and 5 months of after follow-up period, respectively. 5 months before Baseline period Follow-up period 5 months after Follow-up period 2. A diagnosis for cystic fibrosis. 3. A diagnosis for any cancer of respiratory system. 4. Any autoimmune diagnoses identified. 5. A diagnosis for a malignant disease under the treatment at the timing of measurement of blood eosinophil counts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of severe asthma and severe eosinophilic asthma patients | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Number of severe asthma and severe eosinophilic asthma patients with exacerbation(s) 2. Exacerbation over a 12-month Follow-up period 3. Direct medical expenditures associated with Asthma management, management of asthma exacerbation(s) among severe asthma or severe eosinophilic asthma subjects 4. Risk factors for asthma exacerbation among severe asthma patients | — |
Countries
Japan
Contacts
Public ContactHisako Matsumoto
Graduate School of Medicine, Kyoto University Department of Respiratory Medicine
Outcome results
None listed